Carbon monoxide releasing molecules (CORMs) are of current interest due to their potential for controlled administration of small amounts of CO and subsequent beneficial health effects. Previous studies in the Berreau lab have shown that photo-irradiation of a zinc 3-hydroxyflavonolate complex results in oxidative carbon-carbon bond cleavage within the central heterocyclic ring of the flavonol and quantitative CO-release. In the research to be presented, we have examined how changing the diamagnetic metal ion influences the CO-release reactivity. Specifically, we have prepared, characterized, and evaluated the photoinduced CO-release reactivity of 3-hydroxyflavonolate complexes of heavy metal ions (e.g. Pb(II)) and metal ions that have been previously employed in potential therapeutic agents (e.g. Ru(II)). Notably, the results demonstrate that the presence of a heavy metal ion increases the quantum yield for the CO-release reaction.

Heavy metal effects on the photoinduced CO release reactivity of divalent metal 3-hydroxyflavonolate complexes

245th National Meeting (2013)

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