Catalyst and ligand design play a crucial role regarding selectivity control in homogeneous catalysis in general and hydroformylation in particular. While traditional ligand optimization focuses on variation of sterics and electronics, this lecture will show how principles of supramolecular recognition can be applied for both ligand library construction and additional secondary substrate catalyst interactions for substrate activation and selectivity control. Inspired by DNA-base pairing, we developed self-assembling bidentate ligand systems employing complementary hydrogen-bonding. This approach is intrinsically combinatorial and allows the rapid identification of the optimal catalyst by employing an iterative catalyst library deconvolution strategy.The huge rate acceleration in enzyme catalysis is largely due to transition state stabilizing interactions that take advantage of attractive non-covalent interactions. Those principles have been applied by our group, yielding practical and highly efficient supramolecular catalysts for the regioselective hydroformylation of terminal and internal alkenes and tandem hydroformylation/hydrogenation reactions.

Supramolecular catalyst systems in hydroformylation and tandem hydroformylation/hydrogenation

245th National Meeting (2013)

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