The on-going development of the hydroformylation of methyl 3-cyclohexene-1-carboxylate is described. The process development focused on investigating ways to improve the selectivity for the desired isomer over the other possible products. The impact of factors including ligand structure, pressure, and temperature on selectivity were examined. On-line monitoring via NMR was utilized to gain process understanding and a continuous flow process was explored and demonstrated.

Hydroformylation of methyl 3-cyclohexene-1-carboxylate: Searching for selectivity

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.