Technetium-99m is the most widely used medical radionuclide, accounting for over 70% of nuclear medicine procedures (70,000 procedures daily in the US). Serious supply and proliferation issues associated with conventional �HEU fission Mo� generators are leading to intense research into alternative production methods.  We have developed a technology for use on an accelerator employing the reaction Mo-100(p,2n)Tc-99m with a target solution (molybdate) which has several advantages:  Uses the same fluid targetry, cyclotron and infrastructure as presently used for PET isotope production; employs a newly developed automated chemistry unit designed to use a disposable kit to extract the Tc-99m; recycles the Mo-100 for repeated use and processing losses are minimized.  The Tc-99m is produced in high activity concentration and purity and had been used to label a sestamibi kit efficiently.  This method is now being adapted to produce and purify other isotopes such as Cu-64, I-124, Re-186 and Ac-225.

Solution target systems to produce radioisotopes at PET facilities

245th National Meeting (2013)

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