The field of nanomedicine offers significant promise for improving human health by applying the tools of nanotechnology to create and control materials with molecular-level medical effects. The targeting and controlled release of therapeutic agents to specific organs and specific cells in the body is one of the major challenges in developing more effective therapies. This talk will discuss new polymers that have the ability to encapsulate, transport and deliver a variety of cargos. The foundation for this platform is based on our organocatalytic approach to biocompatible/degradable macromolecules with precisely defined molecular weights, end-group fidelity and backbone functionality. These backbones include polylactide, polycarbonate and related degradable polymers with a wide range of backbone functionalities that mimic the rich and diverse functionality of polypeptides. The use of these synthetic methods to generate well-defined macromolecules and their evaluation to test the functional competence of these constructs as drug/gene delivery vehicles will be discussed.

Tailored supramolecular structures for the controlled release of therapeutics

245th National Meeting (2013)

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