This research deals with   developing  novel food grade plant derived polysaccharide delivery system using grafting technique, which allows the efficient delivery of promising anticancer drugs to tumors and reduce the toxicity of cancer drugs. Free radical grafting technique using potassium persulphate redox reaction was used for combining the delivery system and anticancer drugs. The materials were characterized using FTIR, SEM and MS. Fluorescent microscopy and flow cytometry were used to compare the cell internalization and cell death between polysaccharide based delivery system and lipid based delivery system. Grafting was successful in combining the drugs/genes to the delivery system without affecting the properties of the drug and non- toxic nature of the delivery system, thus eliminating the need for linkers. In vitro experiments showed 90% of transfection efficiency and less than 10% of cellular toxicity secondary to treatment compared with other combining techniques and lipid based delivery system.

Plant based polymers as non toxic drug delivery system for chemotherapeutic agents

245th National Meeting (2013)

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