A number of applications in bioengineering, sensing, and microanalysis requires precisely controlled microencapsulation and release. Polymer microcapsules assembled in layer-by-layer fashion have been demonstrated as a promising delivery system for different classes of compounds due to a variety of loading routines and release options, such as spontaneous sustained release, release triggered by chemical and physical-chemical stimuli, and remote physical impact. Patterning of microcapsules on a plane solid substrate introduces the site specificity of release. Capsules in a pattern can be activated as a group or even one by one by remote physical stimulus like illumination with a laser beam. This paper reports on a physical entrapping of polymer multilayer microcapsules in microwells of a pre-patterned substrate and fabrication of polymer multilayer microchamber arrays. The patterned capsules and chambers can be loaded with various actives, serve as microreactors, and be remotely ruptured by a laser beam releasing the content on demand.

Remotely activated patterned polymer microcapsules and microchamber arrays

245th National Meeting (2013)

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