Processing of bioactive molecules into nanoscaled particles (NPs) ensures their improved bioavailability and reduced dose administrations. Additionally, in order to control the localized drug delivery, these nanotherapeutics are used in combination with implantable medical devices. An ideal NPs therapy should provide effective and continuous therapeutic doses over extended periods of time. In this study, nanotherapeutics from various polyphenolic compounds were formulated under sonication. Moreover, hybrid hydrogel-nanotherapeutics devices were obtained by dispersion of polyphenolic NPs in biopolymer solutions prior to their in situ auto- or enzymatically induced gelation. The in vitro NPs release profiles from the platforms were found to be tunable by the gelation mechanism used, e.g. disulfide or enzymatic cross-linking. Finally, the hybrid systems were evaluated for their biocompatibility, capacity to inhibit deleterious wound enzymes and potential to induce wound closure in a specially designed ex-vivo wound model.

Formulation of hybrid biopolymer hydrogels containing phenolic nanoparticles

245th National Meeting (2013)

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