Chronic wounds constitute a major health care problem all over the world partly attributed to persistent production of free radicals and pathogenic bacteria. This work presents for the first time, a dynamic system which is able to continuously quench free radical and inhibit pathogens. This system is based on the ability of phenolic antioxidants to quench free radicals and the ability of cellobiose dehydrogenase (CDH) to reduce oxidized phenolic antioxidants back to the parent compound as well as the ability of CDH  to use oxygen for production of hydrogen peroxide. In vitro incubation of radical generating system with phenolic antioxidants resulted in the oxidation of the respective phenolic antioxidants and addition of the antioxidant regenerating system resulted in the regeneration of the parent compound. Hydrogels loaded CDH hydrogels and supplemented with cellobiose completely inhibited the growth of Stapylococcus aeureus, Bacillus subtilis, Pseudomonas putida and Cellulomonasmicrobium cellulans.

Wound dressing hydrogels with in-built antioxidant and antimicrobial systems

245th National Meeting (2013)

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