The electron-rich heterocycle guanine is the major site of oxidative damage in duplex DNA. Loss of an electron from G initiates a complex cascade of reactions resulting in the formation of several purine and hydantoin products that alter the structure and coding properties of DNA, ultimately leading to mutations. The very plastic energy surface of oxidation pathways led us to pursue collaborative studies with the Schlegel lab to explore plausible reaction intermediates on these pathways. Factors governing the reaction mechanisms and the product outcomes in single-stranded vs. duplex vs. G-quadruplex structures will be discussed.

Mechanistic studies of guanosine oxidation in DNA

245th National Meeting (2013)

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