The impact of core crystallization on the chain exchange kinetics in polymeric micelles is being investigated. Micelles containing diblock copolymers of poly(ethylene oxide) and poly(e-caprolactone) are compared with a structurally similar amorphous analogue. Time resolved-small angle neutron scattering and pulse field gradient NMR are employed to probe single chain exchange and the free unimer concentration, respectively. Fluorescence resonance energy transfer is used to determine the residence time of an encapsulated dye in the micelle core, a model for drug delivery.

Dynamic processes in diblock copolymer micelles with a semi-crystalline core

245th National Meeting (2013)

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