New technology for effecting a variety of transition metal-catalyzed cross-coupling reactions under green chemistry conditions; i.e.,in water at room temperature, will be described. These are enabled by virtue of the �designer� surfactant TPGS-750-M, which quickly forms nanomicelles upon dissolution in water, in which the reactions take place. Representative reactions to be discussed include unpublished results on aromatic aminations, Pd-catalyzed Stille couplings, Cu-catalyzed conjugate additions, and Zn-mediated reductions.

Need to make a bond?  Try it in water at room temperature

245th National Meeting (2013)

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