Photochemistry is a useful tool to affect difficult bond forming events in the generation of architecturally fascinating small molecules. Despite providing rapid access to novel chemotypes and intellectual property space, it is remarkable that it is underutilized in the development of novel scaffolds for drug development. This talk will describe our general program directed towards enhancing molecular diversity using traditional UV photochemistry and visible light mediated photocatalysis. Specifically, the photogeneration of reactive oxyallyl cations from readily available dienones and their intramolecular trapping with dipolarophiles along with the visible light mediated intermolecular free radical coupling of pyrroloindoline radicals with radical acceptors will be discussed. Efforts to evaluate the biological activity of new scaffolds derived from photochemical diversity will also be described.

Photochemical approaches to expanding chemical diversity

245th National Meeting (2013)

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