Daphniyunnine D is a member of the Daphniphyllum alkaloid family, consisting of over 200 molecules. It shows interesting cytotoxic activity against two tumor cell lines, P-388 and A-549 with IC50 values of 3.0 and 0.6 �M, respectively.A novel and reliable route to an advanced tricyclic intermediate (rings ACD) has been developed utilizing an organocatalytic asymmetric intramolecular Diels-Alder reaction as a key step. Demonstrated through a model system, an intramolecular Pauson-Khand reaction provides access to the secondary tricycle DEF.

Towards the total synthesis of daphniyunnine D

245th National Meeting (2013)

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