Copper(II) chloride catalyzes the multicomponent coupling of unactivated ketones with a broad range of amines and terminal alkynes. Equimolar combinations of commercially available starting reagents readily form secondary and tertiary N-propargylamines on fully-substituted carbon centers.

Direct, catalytic access to <i>N</i>-propargylamines bearing fully-substituted carbon centers.

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Direct, catalytic access to N-propargylamines bearing fully-substituted carbon centers.