As synthetic chemists, we increasingly seek methods, techniques and strategies for building complexity into molecular systems. In addition to the challenges of preparing complex materials comes the difficulty of characterizing them, tracking them and observing their behavior in complex environments. This is especially true in the context of self-assembled soft nanomaterials destined for in vivo use. With this in mind, ring-opening metathesis polymerization (ROMP) provides a tool for the generation of well-defined polymers of low polydispersity and highly functionalized architectures. In order to incorporate visualizable labels into amphiphilic ROMP polymers, a variety of fluorescent and MRI contrast agent monomeric units and termination agents have been synthesized, polymerized, and subsequently self-assembled into micellar architectures. The newly formed labeled micellar materials allow for physical characterization via fluorescent lifetime methods, spectroscopy and relaxometry.

MRI agent- and fluorophore-labeled polymers and polymeric micellar nanoparticles

245th National Meeting (2013)

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