Molecular structure of nonfouling polymers regulates surface hydration, which well correlates with their antifouling ability. Here we develop and apply in-house surface plasmon resonance and ELISA to quantify and compare adsorbed proteins on between polyacryamide-based coatings (e.g. polyHEAA and polySBAA) and polyacrylate-based coatings (e.g. polyHEA and polySBMA). All of four polymers containing pendent hydration groups display superlow antifouling properties, but polyHEAA and polySBAA with amide groups are still superior to polyHEA and polySBMA against nonspecific protein adsorption. MD simulations also confirm that polyHEAA and polySBAA exhibit higher surface hydration than polyHEA and polySBMA, due to the enhanced hydrogen-bond formation via amide group and pendent hydration groups. Additionally, incorporation of acid degradable crosslinker into polyHEAA and polySBAA nanogels enables to achieve acid-triggered control-release of model drugs, while still maintaining their ultrastability and minimal cytotoxicity in cellular culture, which holds great potential for tumor-targeted drug carriers.

Improved antifouling property of polyacrylamide with pendent hydration groups

245th National Meeting (2013)

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