Filamentous phage is a biological nanofiber, a bacteria-specific virus, and also a supramacromolecule. Its surface is made of coat proteins that can be genetically modified to display foreign peptides. This talk will cover three major topics on the use of phage for developing nanomedicines and biomaterials. I will first introduce the identification of peptides that can selectively target cancer cells, stem cells or tumor tissue from a phage-displayed random peptide library. I will then describe the use of the targeting peptides to develop novel nanoparticles for targeted drug delivery to cancer cells as well as enhanced gene delivery to stem cells. Finally, I will highlight the use of genetically engineered phage for directing stem cell differentiation and tissue regeneration.

Phage-enabled cell-targeting, drug and gene delivery and tissue engineering

245th National Meeting (2013)

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