Phenylarsonic acid is a derivative of the organo-arsenic compounds roxarsone and para-arsanilic acid. Exposure to these compounds has caused respiratory problems among workers who handled them in animal feed processing factories.  Since analytical methods exist for roxarsone and para-arsanilic acid, this work developed a method to detect  phenylarsonic acid.  For simplicity and cost effectiveness, the method uses High Performance Liquid Chromatography. With a wavelength of 263 nm and a mobile phase of 50% water v/v, 48% methanol v/v, and 2% glacial acetic acid v/v, linearity over a range of analyte concentrations from 0.5 to 2 times the Permissible Exposure Limit (PEL) was observed. Glass fiber filters were determined to be a good sampling media for collection of the analyte. Percent recoveries from the filters were calculated for various spiked concentrations of the PEL. Results from storage and stability studies of filters spiked with 1 x PEL will also be reported.

Development of an analytical method for the detection of phenylarsonic acid in air

245th National Meeting (2013)

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