One of the most prominent methods for therapeutic gene delivery is lipofection using cationic liposomes for the complexation, transport and release of nucleic acids into cells. Lipofection vectors are safe to consider for medical purposes as little mutational or toxicological risk exist.Dioctadecyldimethylammonium Bromide/Chloride (DODAB/C): Monoolein (MO) liposomes have recently been reported to successfully promote animal cell transfection. The presence of MO, which serves as helper lipid in lipoplex formulations, influences the physicochemical properties of DODAB/C:MO liposomes and derived lipoplexes. Furthermore, lipoplex characteristics affect the interaction with extracellular components, uptake by cells and intracellular trafficking. The high biocompatibility of pDNA:DODAB/C:MO lipoplexes further supports this as a new gene therapy vector, using MO as new helper lipid in lipofection.

Dioctadecyldimethylammonium bromide/chloride: Monoolein liposomes for nucleic acid delivery

245th National Meeting (2013)

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