The self-assembly of amphiphilic block copolymers is dictated primarily by the balance between the hydrophobic core volume and the hydrophilic corona.  In these studies, amphiphilic diblock, triblock and star copolymers containing poly(lysine) (PK) and poly(glutamic acid) (PE) were synthesized and their solution properties studied using dynamic light scattering, circular dichroism spectroscopy and transmission electron microscopy.  These materials are shown to respond to pH, due in part to the helix-coil transition in the peptide chain, but also due to changes in curvature of the assembly at the interface.  We exploit the responsiveness of these materials to encapsulate and release therapeutics such as doxorubicin and demonstrate the potential to achieve triggered release as a function of pH due to morphology transitions.

Responsive peptide-based triblock and star copolymers for delivery of therapeutics

245th National Meeting (2013)

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