Titanium Dioxide nanoparticles can be functionalized with a variety of aldehyde, amine, or silane groups under �simple� chemical conditions. The hydroxy groups surrounding the oxidized titanium are susceptible to react with a collection of practical chemicals that allow for antibody and protein attachments. Dopamine, 3,4 dihydroxybenzaldehyde, and APTS have produced consecutive results. Though not in substantial quantities, confirmations of attachment to the Titanium Dioxide nanoparticles were characterized using 1H, 13C-NMR and IR. Techniques and methods were transferred to Oxidized Titanium plates, where X-ray photoelectron spectroscopy was used to quantify surface binding. Surface functionalization of Titanium metal has been investigated to construct reliable ventricular assist devices. Current devices oppose natural biological flow through the tubular structure, presenting problems with specific protein buildup. The goal is to investigate and quantify functionality on Titanium nanoparticles to eventually transfer data and methods to use for alternate antibody and protein attachments to Titanium metal.

Functionalization of titanium nanoparticles and titanium plates

245th National Meeting (2013)

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