LiquiScan-ES is a versatile ion mobility spectrometry system that relies on first-principle analysis to determine the size and molecular weight of nanoparticles, macromolecules, and complexes in the range of 2.5 nm to ~ 1 �m (8 kDa to > 80 MDa). Droplets produced by an electrosprayed analyte solution are neutralized, resulting primarily in singly charged ions. The sizing of the ions in a gaseous state is accomplished by differential mobility analysis in an electrical field and subsequent detection by condensation particle counting. Samples can be analyzed rapidly and reproducibly with high resolution, sensitivity, and accuracy in comparison with standard analytical methods. This technique is also independent of the optical properties of the analyte and solvent and can produce an accurate measurement of multimodal distributions. Indeed, LiquiScan-ES has proven to be a valuable tool for analyzing and quantifying nanoparticles and macromolecules such as proteins, DNA, carbohydrates, polymers, and aggregates. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/242nm/uploads/92056_figure.jpg' alt='' />

Nanoparticle and protein size analysis by LiquiScan-ES

245th National Meeting (2013)

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