Mechanical patterns on cell culture substrates can be potentially used as effective cues in directing cell migration. Fully functional substrates require not only readily tunable modulus but also proper surface properties to ensure proper interactions with the surrounding media. In this study, crosslinked poly(dimethylsiloxane) (PDMS) with tunable modulus ranging from 50 to 1000 kPa was fabricated using platinum-catalyzed hydrosilylation from vinyl and -SiH functionalized prepolymers. To overcome hydrophobicity of the PDMS surface, vinyl-terminated poly(ethylene glycol) (v-PEG) was grafted onto crosslinked PDMS thin films containing excess -SiH functionality via surface hydrosilylation reaction. Efficiency of surface PEGylation is controlled by surface density of -SiH groups, molecular weight of v-PEG, and catalyst concentration.

Preparation and subsequent surface PEGylation of crosslinked poly(dimethylsiloxane) substrates with tunable moduli

245th National Meeting (2013)

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