Nitric oxide (NO) is a molecule that has significant biological consequences. It is involved in signaling pathways, acts as a vasodilator, and can cause dispersal of biofilms in the human body. This project was designed to create a nitric oxide (NO) releasing film that was responsive at biological conditions. Previous research has shown that S-nitroso-N-acetyl-D,L-penicillamine (SNAP) liberates NO at biological temperatures (37 �C) but IS stable at room temperature. Here, SNAP was immobilized on a substrate (stainless steel 316L) using a self-assembled monolayer of 12-aminododecanoic acid. First, the amine terminus of the monolayer was functionalized with N-acetyl-L-penicillamine (NAP). Then, the thiol group of the NAP was converted to a thionitrite group yielding an even monolayer of SNAP on a model substrate. Reactions were analyzed by surface infrared spectroscopy and MALDI-TOF MS.

Nitric Oxide (NO) release from self-assemled monolayers

245th National Meeting (2013)

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