Ingestion of As in food and soil ingestion is an important exposure pathway and often is the �risk-driver� for As-contaminated soil and urban gardens.  Arsenic exposure from food and soil ingestion depends on its bioaccessibility (e.g., the amount dissolved in the gastrointestinal tract) and the subsequent absorption of the As across the gut epithelium (e.g. bioavailability).  Arsenic relative bioavailability in soil and food has been reported to range from <10% to 100%.  Phosphate, iron and other chemical constituents in food and soil can greatly increase or decrease As bioavailability. Recently, research effort has been directed toward the development of in vitro gastrointestinal (IVG) methods to simulate human gastrointestinal conditions and estimate bioavailable As. Application of  IVG methods to measure As bioavailability in food and soil will be presented.  Future directions including application of IVG methods to evaluate practices that reduce As bioavailability in contaminated food and soil will be discussed.

Using in vitro gastrointestinal bioaccessibility methods to measure arsenic bioavailability and risk from ingestion of food and soil

245th National Meeting (2013)

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