Pyrimidine derivatives bearing amino substituents have been of multifold biological and pharmacological interest. In order to speed up lead identification for drug discovery, the application of high throughput parallel synthesis (HTPS) has become an important target. It is also well known that SNAr reaction has become a useful and efficient synthetic protocol.Herein, a focused library of pyrimidine derivatives was rapidly synthesized in parallel reactor via SNAr displacement and progress of all reactions was monitored by UPLC and LCMS. All library compounds were further screened for kinase activities leading to the identification of interest hit.

Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis

245th National Meeting (2013)

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