Previously m-amsacrine has shown promise in its use as an anti-tumor agent however, due to its short half-life and the formation of dangerous byproducts through breakdown, the interest in the formation of new agents is of interest. Progress on the design and synthesis of additional 9-aminoacridine derivatives are investigated later. The synthesized 9-aminoacridines contain potential hydrogen bonding sites in hope to prevent hydrolysis at physiological pH and increase binding in spite of poor sequence specificity. The target compounds were synthesized, purified, and evaluated on genomic DNA for their ability to intercalate as identified through thermal denaturation studies and viscosity titrations. The results of the evaluation will be presented.

Evaluation of the biological binding abilities of synthesized anti-tumor aminoacridines

245th National Meeting (2013)

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