New ferrocenecarboxylate derivatives were synthesized and biologically examined in vitro with colon cancer cells (HT-29) and breast cancer cells (MCF-7). Ferrocenecarboxylic acid was first activated with oxalyl chloride. The acyl chloride formed was added dropwise into a solution containing different phenolic compounds to form the ester. After extraction, the compound was purified by column chromatography using silica as stationary phase and eluted with dichloromethane (same solvent used in most stages of the reaction). The esters were characterized by FTIR spectroscopy, NMR spectroscopy and X-Ray Crystallography. The cytotoxicity studies were performed by the MTT biological assay using HT-29 and MCF-7 cell lines. Ferrocene has no significant cytotoxicity, but as moiety in organic molecules, it that can be transported into the cell having anti proliferative effect by its well known redox properties. Recent results show promising candidates for anti-cancer drug development.

New ferrocenecarboxylate derivatives: Synthesis, characterization, and in vitro antitumor activity study on human colon carcinoma cells (HT-29) and human breast cancer cells (MCF-7)

245th National Meeting (2013)

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