A novel preparation of the radiotracer [18F]4-fluoro-L-phenylalanine, a potential PET imaging agent for the detection of gliomas, is reported. The goal of this project was to further demonstrate the utility of diaryliodonium salt intermediates in the synthesis of high specific activity [18F]fluorinated amino acids using (n.c.a.) [18F]fluoride. The diaryliodonium salt 1  precursor was synthesized in high yield from commercially available L-phenylalanine according to previously reported methods.1 Fluorination of 1  with Kryptofix potassium [18F]fluoride, followed by a rapid deprotection with HI, provided the radiotracer in good yield. Preliminary radiofluorination reactions employing the precursor 1  provided a 25% RCY (unoptimized, EOB) of n.c.a-[18F]-4-fluoro-L-phenylalanine (determined by radio-HPLC).References:  1Wang, B; Qin, L; Neumann, K D; Uppaluri, S; Cerny, R L; DiMagno, S G; Org. Lett. 2010,  12,3352-3355.

Highly efficient synthesis of no-carrier-added [<sup>18</sup>F]-4-fluoro-L-phenylalanine

245th National Meeting (2013)

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Highly efficient synthesis of no-carrier-added [18F]-4-fluoro-L-phenylalanine

Highly efficient synthesis of no-carrier-added [¹⁸F]-4-fluoro-L-phenylalanine