Opioid receptors are important class of GPCRs which deal with the analgesic effects in humans. Opioid analgesics are widely used in the managemet of neuropathic pain. The clinical use of opioids is limited by serious side effects. � receptors are the most important receptor target for almost all commercially available potent opioid agonist. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/242nm/uploads/87533_figure_1.jpg' alt='' /> Here we designed and synthesized novel �-selective opioid ligands of N-phenyl-N-(piperidin-4-yl) proionamide derivatives which contain the (5-amino/hydroxyl tetrahydronaphthalen-2yl) methyl group. Basically our designs are based on fentanyl the well known potent �-agonist in which we replaced the phenethyl group with the tetrahydronaphthalen-2yl methyl moiety with amino, and hydroxyl and opioid peptide analog substitution at the 5thposition. 1. Supported by USPHS, NIDA2. WO00/71518A2, WO2009/0775843. Expert Opin. Drug. Discov. 2010 , 5, 10

Design and synthesis of novel N-phenyl-N-(piperidin-4-yl) propionamide derivatives and their use as opioid receptor ligands

245th National Meeting (2013)

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