The research presented involves the synthetic diversification and biological evaluation of a parent chemotype of an antagonist of the recently de-orphanized cannabinoid-like G-protein coupled receptor, GPR55. The parent molecular scaffold is a compound that selectively antagonizes GPR55, displaying no activity at any of the other similarly structured cannabinoids. By rationally varying substituents to maximize the various interactions between the binding pocket and the ligand, the efficacy and the selectivity of ligands for GPR55 can be modified.

Exploration and maximization of GPR55 antagonists using synthetically diversified ligands

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.