Apolipoprotein E (apoE) is a prominent transportlipoprotein in the body and brain that helps distribute cholesterol andtriglycerides between organs in the human body. Genetic variance in apoE alleles has been shown to increase theprobability of developing Alzheimer's disease. We have previously screened a small library of small molecules that identifiedtwo structurally diverse scaffolds. Specific chalcones have previously shownthe ability to modulate the production of apoE in ELISA assays.  This presentation aims at describing ourefforts with further structure-activity relationship (SAR) studies in anattempt to improve efficacy and develop drug-likeness.

Development of small chalcone and chalcone-likeorganic molecules for apolipoprotein E (apoE) modulation throughstructure-activity relationship (SAR) study

245th National Meeting (2013)

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