Multidrug-resistant Gram-negative bacteria (Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae) are a serious threat to human health.  The polymyxin class of antibiotics is one of the last lines of defense for treating infections caused by these pathogens.  We have synthesized novel Dap-3 polymyxin analogs that exhibit greater potency against polymyxin resistant recent clinical isolates without losing activity against susceptible strains.

New polymyxin analogs for the treatment of multidrug-resistant gram-negative nosocomial pathogens

245th National Meeting (2013)

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