Pseudomonas aeruginosa (PA) is the prevalent pathogen in the lungs of chronic Cystic fibrosis (CF) patients. Over time PA strain in CF patients mutates to mucoid strain that overproduce alginate and form biofilm with increased antibiotic resistance. Here we report, a nontoxic polyol-derivatized hydrocarbons that inhibits biofilm formation and disperses 3-day old already formed biofilm of wild type and mucoid PA strains. Polyol-derivatized hydrocarbons also reduced the extra polymeric substances secreted by mucoid PA as shown in figure .

Non-microbicidal inhibition and dispersion of mucoid <i>Pseudomonas aeruginosa</i> biofilm by polyol-derivatized hydrocarbons

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Non-microbicidal inhibition and dispersion of mucoid Pseudomonas aeruginosa biofilm by polyol-derivatized hydrocarbons