Inorganic nanoparticles (NPs) with tunable and diverse material properties hold great potential as multimodal imaging probes for better disease management. However, the unsuitable pharmacokinetics and severe nonspecific accumulations of inorganic NPs after systemic administration significantly hamper their clinical applications. Thus, multifunctional nanoprobes with optimal in vivo pharmacokinetics and efficient clearance are highly desirable. Here, we report a one-step synthesis of NIR-emitting radioactive glutathione-coated [198Au]AuNPs with quantitative labeling yield and 100% purity. The pharmacokinetic and biodistribution studies showed that these nanoprobes exhibit a rapid diffusion half-life of 5.0 min and a desirable elimination half-life of 12.7 h with more than 50% of injection dose cleared out of body after 24 h, which is comparable to those of the clinically available small molecule contrast agents but different from those of most known nanoprobes. The readily detection of these NIR-emitting radioactive [198Au]AuNPs with both SPECT and fluorescence imaging techniques suggested that they might serve as dual-modality imaging probes in the future.References:[1] Zhou et al., Angew. Chem. Int. Ed, 2011, 3168-3172.[2] Zhou et al., Angew. Chem. Int. Ed, 2012, 10118-10122.

Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics

245th National Meeting (2013)

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