Plants and prokaryotes rely on the methionine salvage pathway for the production of polyamines and ethylenes, both crucial for cell growth and proliferation.  Nickel Acireductone dioxygenase (Ni-ARD) is a metalloenzyme present in this pathway.  A family of related pyridyl and phenoxy containing Ni and Zn complexes were synthesized and characterized as models of the active site of Ni-ARD. Through small modifications of the ligand backbone in the metal complex, and analyzing the structural and electronic changes that result from these alterations, a better understanding of the structure-function relationship of the active site of Ni-ARD is being pursued.

New family of model complexes for the active site of Ni-ARD using nitrogen and oxygen containing ligands

245th National Meeting (2013)

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