Molecular recognition is a biological phenomenon and occurs spontaneously in many biochemical processes. Because of the ability to act as H-bond donors, urea and thiourea-based neutral receptors are potential to bind anions.  These classes of receptors bind anions strongly through NH���� anion interactions, and could be useful as extractants, separations, and sensors for anions. In this study, wehave synthesized two urea-based tripodal receptors functionalized with amine- and cyno-groups and studied their comparative binding properties in solution and solid state. From the NMR titrations, we observed that the p-cyano functionalized receptor shows higher binding affinity than the p-amino functionalized analogue. Furthermore, NOESY NMR experiments support the binding of halides and oxoanions in the solution. In this poster, we will present the comprehensive binding studies of these two compounds in both solution and solid state. Acknowledgement: The NSF is acknowledged for a CAREER award (CHE-1056927) to MAH.

Comparative anion binding study of p-substituted tripodal tris-urea receptors

245th National Meeting (2013)

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