A facile synthesis of bis-isoxazoles by 1, 3 dipolar cycloaddition reactions of isoxazole-4-carbaldehyde oximes and alkynes under catalysis of tetrabutylammonium bromide (TBAB) as phase transfer catalyst (PTC) in toluene-water biphasic solvent has been explored.  Overall, mild reaction conditions, enhanced rates, improved efficiency of reaction with maximum atom economy, use of inexpensive catalyst and green solvent system and reduced reaction time are the remarkable features exhibited by our process. The technology was demonstrated to be applicable to the synthesis of a host of chemical hybrids.

Phase transfer catalysed synthesis of bis-isoxazoles: 1, 3 Dipolar cycloaddition of isoxazole-4-carbaldehyde oximes and alkyne in toluene-water biphasic system

245th National Meeting (2013)

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