Layer-by-Layer assembly is a versatile approach for incorporating a broad range of materials on surfaces based on complementary molecular interactions. As such, LbL offers a high degree of control over the composition of a given material system, with the ability to tune film properties for an array of applications. Using this methodology, we are investigating LbL on nanotherapeutics to impart functionality and to facilitate more efficacious delivery of therapeutics, including synergistic drug combinations. We are also developing a scalable platform for fabrication of these systems in a highly controlled manner by incorporating PRINT nanoparticle technology, presenting exciting opportunities towards reproducibly generating systems that are highly attractive with regard to approval through regulatory pathways as well as industrial manufacture of nanotechnology.

Layer-by-layer functionalized nanotherapeutics

245th National Meeting (2013)

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