Cellular Backpacks are nanoscale thick, cargo carrying assemblies that can be attached to a living cell to provide additional function and capability.  When synthetic backpacks are attached to immune system cells such as T-cells and phagocytes, the desired cargo is a therapeutic drug that can be released on demand after the cell reaches the disease site of interest.  In this talk, strategies for attaching cellular backpacks based on polyelectrolyte multilayers will be discussed including schemes for the covalent attachment of backpacks to living cells.  The use of stimuli-response polymers for both fabricating backpacks and on-demand release of drugs from backpacks will be described.  In the former case, a detailed characterization of stimuli-responsive hydrogen-bonded multilayers by techniques such as depth profiling XPS will be presented along with suitable design requirements for their use in the fabrication process.

Cellular backpacks based on stimuli-responsive multilayers

245th National Meeting (2013)

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