The layer-by-layer (LbL) technique has found widespread use for the nanoscale engineered assembly of materials, as it is simple, versatile and allows precise control over film properties such as thickness and morphology. Recently, there has been emphasis on the development of LbL capsules specifically engineered to respond to specific stimuli for therapeutic delivery applications or as microreactors.The preparation of LbL polymer capsules stabilized by a combination of 'click chemistry' and disulfide cross-linking is reported. The capsules obtained possess gatable permeability due to the reversible character of the latter cross-linking. Their pH responsive behavior as well as their permeability using a series of labeled dextrans was investigated in both the 'closed state' (CuAAC and disulfide cross-linking intact) and the 'open state' (CuAAC cross-linking intact). The potential of the capsules to reversibly encapsulate DNA was demonstrated.

Dual stabilized nanoengineered polymer capsules

245th National Meeting (2013)

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