Nanoparticles are receiving increasing attention since they have properties that are significantly different than those of bulk materials. Organic-inorganic composites are vital in biological, medical, and chemical applications. Among them, core-shell composite nanoparticles are a unique class of materials which are attractive for their potential applications as delivery vehicles (for drugs, dyes, cosmetics, ink etc.). In this presentation, we report the synthesis of core-shell composite nanoparticles through one-step Pickering emulsion polymerization. The polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles are temperature sensitive, demonstrate effective drug release upon volume change, and show promising cytotoxicity results in prostate cancer therapy. The thermal transition temperature can be tuned by incorporating additional co-monomers, co-solvents, and ionic surfactants.  In addition, we have successfully synthesized polystyrene/poly(N-isopropylacrylamide)-gold core-shell and asymmetric composite particles.

Core-shell composite particles: Synthesis, characterization, and application

245th National Meeting (2013)

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