Neuroblastoma is the most common extracranial solid tumor in children. The difficulty in treating neuroblastoma lies in its inherent complexity and mechanisms of drug resistance. The reasons for drug resistance in neuroblastoma include drug efflux, cancer stem cells, hypoxic regions within tumor cells, IMR-32 neuroblastoma cells were incubated with 0-0.15% (v/v) of ginger oil standardized to its eucalyoptol content, under normoxic or hypoxic conditions with 150 �M of CoCl2 and incubated at 37�C and 5% CO2in a humidified incubator for 72 h. Eucalyptol up to 10 �M was ineffective but ginger oil at 0.075% (v/v) significantly decreased IMR-32 cancer cell viability, induced cell death by apoptosis, down-regulated the expression of HIF-1a under hypoxic conditions, and down-regulated Hsp90 a, VEGF, Akt, and bax, and the expression of CD133, CD24, and ABCG2. The efficacy of ginger oil against neuroblastoma cells is not associated with eucalyptol.

Ginger terpenes inhibit cancer stem cells in hypoxic neuroblastoma cells

245th National Meeting (2013)

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