In most biopharmaceuticals processes, the downstreampurification is dominated by chromatographic separations, which require thepreparation, holding and distribution of numerous buffer solutions. Bufferpreparation is a potential process bottleneck in high-capacity situations. Thispaper examines the use of macroscopic modeling techniques to evaluate bufferpreparation for downstream processing. Cases studies will address thechallenges in buffer preparation for multi-line facilities (that share bufferprep tanks), the impact of disposable containers on the demand for utilitiesand the cost of goods, and the effect of increases in bioreactor titer.

Modeling buffer preparation operations for downstream processing

245th National Meeting (2013)

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