The outer coordination sphere of enzymes is essential to the selectivity, specificity and high rates that are realized by nature's catalysts.  This is achieved by careful control of substrate and product movement, the active site environment, redox potentials and the use of dynamics to control reactivity.  Incorporating these features into molecular catalysts may be essential to attain similar reactivity and control.  In this work, we will discuss our recent results in utilizing peptides to modulate the reactivity of homogeneous catalysts, in the areas of hydrogen production and oxidation, as well as hydrogenation.  Based on these results, we will discuss needed future directions in this new area of study.

Using a peptide-based outer coordination sphere to control molecular catalysts

245th National Meeting (2013)

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