The ruthenium(II) polypyridyl complex [(phen)2Ru(tatpp)Ru(phen)2]Cl4 is a promising anti-tumor agent. It has shown biological activity by cleaving DNA under anaerobic conditions and has shown good cytotoxicity against many cancer cell lines. Analogous lipophilic compounds, [(Ph2phen)2Ru(tatpp)Ru(Ph2phen)2]Cl4, (Ph2phen, 4,7-diphenyl1-1,10-phenanthroline), [(Me4phen)2Ru(tatpp)Ru(Me4phen)2]Cl4,  (Me4phen, 3,4,7,8 tetramethyl-1,10-phenanthroline),  [(Me4phen)2Ru(tatpp)]Cl 2, [(Ph2phen)2Ru(tatpp)]Cl2, have been prepared and characterized by NMR, CHN and MS. This paper will present the results from a structure activity study on the cytotoxicity against malignant tumor cell lines and mouse maximum tolerable dose.

Lipophilic ruthenium(II) polypyridyl complexes for increased cytotoxicity and reduce animal toxicity

245th National Meeting (2013)

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