The chemistry of carbon monoxide releasing molecules (CORMs) is of current interest due to the identification of several positive health benefits from the controlled administration of small amounts of CO. CORMs that exhibit controlled, photoinduced CO-release reactivity (photoCORMs) are of particular current interest. Most photoCORMs investigated previously have several drawbacks, such as the requirement of UV light for photoinduced CO-release, reversibility of the CO-release reaction, and the production of potentially reactive low-valent metal photo-remants. Previous studies in our laboratory have shown that 3-hydroxyflavonolate complexes of divalent metal ions undergo quantitative, non-reversible photoinduced CO-release in the presence of O2. In this contribution, we will describe the synthesis, characterization, and photoinduced CO release reactivity of a new family of photoCORMs based on zinc complexes containing an anionic 3-hydroxy-4-pyrone type ligand. Notably, these complexes exhibit photoinduced CO release using visible light and in mixed organic/aqueous solutions.

New family of photoCORMs: Photoinduced CO release in zinc 3-hydroxy-4-pyrone complexes

245th National Meeting (2013)

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