A one step synthesis of aryl phosphine oxides was discovered using Grignard reagents to convert aryl phosphonates directly. These reactions are mediated by Lewis acid catalysts and provide a convent way to access a wide variety of aryl phosphine ligands without the need for air or moisture sensitive precursors in fair yields.

Phosphine ligand synthesis: Direct conversion of aryl phosphonates to aryl phosphine oxides via Grignard reagents and Lewis acid catalysts

245th National Meeting (2013)

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