We have developed a block-copolymer-directed, kinetically-controlled self-assembly process called Flash NanoPrecipitation (FNP) to produce 50-400 nm nanoparticles. The process involves controlling micromixing to effect supersaturations as high as 10,000 in 1.5 ms, and then controlling nucleation and growth rates to match block copolymer assembly rates. The rapid assembly enables the encapsulation of multiple drugs and imaging agents into the same nanoparticle, and the production of multivalent targeted nanoparticles.   We will give examples of nanoparticle assembly and focus on targeting and imaging applications. Imaging using long wavelength fluorphores, MRI contrast agents, and SPEC agents will be presented.  An example of TB treatment combining multiple drugs and targeting made is a single step process shows the versatility of the FNP assembly. The FNP process enables the production of nanoparticle libraries with variable ligand density. Examples of small molecule (mannose for TB), folate ligand, and antibody targeting will be presented. For the mannose targeted nanoparticles we show a maximum ligand density for uptake into macrophages, and a reduce uptake beyond this maxium value. Finally, the rules for block copolymer selection on circulation time will be addressed.

Flash NanoPrecipitation enables the production of nanoparticle drug cocktails and multivalent targeted nanoparticles for imaging and drug delivery

245th National Meeting (2013)

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